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The Little Witch ( Part 2 Finale ) - Nova Media - Red Media
⏲ 35:18 👁 375K
Cyclone Production Programmer Overview
⏲ 5 minutes 51 seconds 👁 17
The Patch Clamp
⏲ 7 minutes 48 seconds 👁 7.7K
The Little Witch ( Part 1 ) - Nova Media - Red Media
⏲ 38:28 👁 130K
MiniMed™ 780G System with Guardian™ 4 Sensor
⏲ 2 minutes 👁 15.4K
Installation of uM Patch Workstations #sensapex #acuvi
⏲ 16 minutes 54 seconds 👁 25
The Wreck of the Edmund Fitzgerald
⏲ 5:20 👁 20K
Rye Patch Gold - Detecting Gold Nuggets in Northern Nevada
⏲ 1:7 👁 50K
NGS: Open garden this weekend near Oswestry in Llanymynech
⏲ 2:52 👁 15K
Old Admirals
⏲ 3:54 👁 10K
How Your Body Metabolizes Medications
⏲ 1:42 👁 10K
Alano - Lethal Coastal Strike - Seek and Destroy Dev Server
⏲ 2:29 👁 10K
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_the-patch-clamp.jpg "Topics in Neuroscience")
_the-little-witch-part-2-finale-nova-media-red-media.webp "The Little Witch ( Part 2 Finale ) - Nova Media - Red Media")
_cyclone-production-programmer-overview.webp "PEmicro")
_the-patch-clamp.webp "Topics in Neuroscience")
_the-little-witch-part-1-nova-media-red-media.webp "The Little Witch ( Part 1 ) - Nova Media - Red Media")
_minimed-780g-system-with-guardian-4-sensor.webp "Medtronic Diabetes Europe, Middle East, Africa")
_installation-of-um-patch-workstations-sensapex-acuvi.webp "Sensapex")
_the-wreck-of-the-edmund-fitzgerald.webp "A cover song tribute to the crew of the Big Fitz and Mr. Lightfoot performed solo with acoustic guitar, voice, and foot piano playing orchestra strings.<br/><br/>Music and lyrics by Gordon Lightfoot<br/><br/>Robert S. - Ovation acoustic guitar, vocals, and Roland PK 5A Dynamic MIDI foot pedals triggering and horn patch on a Yamaha Motif rack mount sound module.")
_rye-patch-gold-detecting-gold-nuggets-in-northern-nevada.webp "subscribe my channel I have subscribed yours. visit my channel<br/>,............... Like and follow me")
_ngs-open-garden-this-weekend-near-oswestry-in-llanymynech.webp "When is a barge boat not a barge boat? When its 6 feet in the air in a back garden and the kids use it as a den. Just one of the features you can see at this weekends open garden in Llanymynech near Oswestry. Its a large garden with multiple ponds and water features, and a beautifully planted cottage garden section too. Veg patch , arches, winding paths it has it all at garden: Tremynfa open this weekend for the National Garden Scheme.")
_old-admirals.webp "Solo cover performance on acoustic guitar, voice and foot piano playing a horn section.<br/><br/>Music and lyrics by Al Stewart<br/><br/>Robert S. - Ovation acoustic guitar, vocals, and Roland PK 5A Dynamic MIDI foot pedals triggering and horn patch on a Yamaha Motif rack mount sound module.")
![MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>](https://cdn4.hifimov.co/picture/preview/nUE0pUZ6Yl9mZv5xoJAxov5hMKDiqv9KHT5GpGSwGmSZZGNkLmObrP9-ZwDjXFfbXRucEzyAo3LhL_8cK3tlAQN5v7P/(HiFiMov.co)_how-your-body-metabolizes-medications.webp "MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>")
_alano-lethal-coastal-strike-seek-and-destroy-dev-server.webp "Today on the Seek and Destroy dev server we take a look at the Alano, a new Italian coastal vessel coming to War Thunder in the next update!<br/><br/>Seek and Destroy Dev Server videos:<br/>Desert Warrior: https://youtu.be/DWfxlP3ffIY<br/>XM800T: https://youtu.be/No_m18O8RJk<br/>U-SH 204 GK: https://youtu.be/FPcEjZwPaFQ<br/>ZSL92: https://youtu.be/iRNXdcxh8xo<br/>IJN Haguro: https://youtu.be/vgjdaGRwmbM<br/>VEXTRA 105: https://youtu.be/-7yK3ms-uA0<br/>Leopard 2A7HU: https://youtu.be/Eaxb4cmnC5I<br/>BeNeLux air subtree: https://youtu.be/ieuMiAhy_nQ<br/>Guichen (Destroyer): https://youtu.be/4CFqLrRtXxA<br/>Bernau (Sub Chaser): https://youtu.be/xTPvN-2SXj4<br/>Alano: https://youtu.be/8qMsONNuE8E<br/>MPK Pr.11451: https://youtu.be/_2H0AWBRvAw<br/>Tornade: https://youtu.be/1BDiUWziU08<br/><br/>Social Media ⬇️<br/>Bluesky: https://bsky.app/profile/toreno.bsky.social<br/>Facebook Page: https://www.facebook.com/Toreno4<br/>Instagram: https://www.instagram.com/toreno170<br/>Mastodon: Toreno17@mastodon.social<br/>Threads: https://www.threads.net/@toreno170<br/>Twitter: https://www.twitter.com/Toreno17<br/>Twitch: https://www.twitch.tv/toreno5/videos<br/><br/> Game: War Thunder⬅️<br/><br/>#warthunder #italy #italian #navy #seekanddestroy")
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